Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 8759764, 9 pages
https://doi.org/10.1155/2017/8759764
Research Article

Antigenotoxic Properties of Agaricus blazei against Hydrogen Peroxide in Human Peripheral Blood Cells

1Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
2Department of Chemistry, Faculty of Veterinary Medicine, University of Belgrade, Belgrade, Serbia
3Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
4Laboratory for Radiobiology and Molecular Genetics, Institute for Nuclear Research “Vinca”, University of Belgrade, Belgrade, Serbia

Correspondence should be addressed to Lada Živković; sr.ca.gb.ycamrahp@adal

Received 21 September 2016; Revised 31 October 2016; Accepted 11 January 2017; Published 21 February 2017

Academic Editor: Chung-Yen Oliver Chen

Copyright © 2017 Lada Živković et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Wasser, “Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides,” Applied Microbiology and Biotechnology, vol. 60, no. 3, pp. 258–274, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. R. W. Kerrigan, “Agaricus subrufescens, a cultivated edible and medicinal mushroom, and its synonyms,” Mycologia, vol. 97, no. 1, pp. 12–24, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Firenzuoli and L. Gori, “Herbal medicine today: clinical and research issues,” Evidence-based Complementary and Alternative Medicine, vol. 4, no. 1, pp. 37–40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Hetland, E. Johnson, T. Lyberg, S. Bernardshaw, A. M. A. Tryggestad, and B. Grinde, “Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer,” Scandinavian Journal of Immunology, vol. 68, no. 4, pp. 363–370, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. S.-J. Huang and J.-L. Mau, “Antioxidant properties of methanolic extracts from Agaricus blazei with various doses of γ-irradiation,” LWT - Food Science and Technology, vol. 39, no. 7, pp. 707–716, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. A. E. S. S. Carvajal, E. A. Koehnlein, A. A. Soares et al., “Antitumor-active heteroglycans from niohshimeji mushroom, Tricholoma giganteum,” Bioscience Biotechnology and Biochemistry, vol. 59, no. 4, pp. 568–571, 1995. View at Google Scholar
  7. R. D. Delmanto, P. L. A. De Lima, M. M. Sugui et al., “Antimutagenic effect of Agaricus blazei Murrill mushroom on the genotoxicity induced by cyclophosphamide,” Mutation Research, vol. 496, no. 1-2, pp. 15–21, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. R. C. R. N. Menoli, M. S. Mantovani, L. R. Ribeiro, G. Speit, and B. Q. Jordão, “Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells,” Mutation Research - Genetic Toxicology and Environmental Mutagenesis, vol. 496, no. 1-2, pp. 5–13, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. M. F. Bellini, N. L. Giacomini, A. F. Eira, L. R. Ribeiro, and M. S. Mantovani, “Anticlastogenic effect of aqueous extracts of Agaricus blazei on CHO-k1 cells, studying different developmental phases of the mushroom,” Toxicology in Vitro, vol. 17, no. 4, pp. 465–469, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. R. Guterrez, M. S. Mantovani, A. F. Eira, L. R. Ribeiro, and B. Q. Jordão, “Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro,” Toxicology in Vitro, vol. 18, no. 3, pp. 301–309, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. P. H. Gameiro, J. S. Nascimento, B. H. G. Rocha, C. F. B. Piana, R. A. Santos, and C. S. Takahashi, “Antimutagenic effect of aqueous extract from agaricus brasiliensis on culture of human lymphocytes,” Journal of Medicinal Food, vol. 16, no. 2, pp. 180–183, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. da Rosa Guterres, M. S. Mantovani, A. F. da Eira, L. R. Ribeiro, and B. Q. Jordão, “Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells,” Genetics and Molecular Biology, vol. 28, no. 3, pp. 458–463, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. R. C. Luiz, B. Q. Jordão, A. F. Da Eira, L. R. Ribeiro, and M. S. Mantovani, “Non-mutagenic or genotoxic effects of medicinal aqueous extracts from the Agaricus blazei mushroom in V79 cells,” Cytologia, vol. 68, no. 1, pp. 1–6, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Savić, A. Patenković, M. Soković, J. Glamočlija, M. Andjelković, and L. J. L. D. van Griensven, “The Effect of Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al., extract on methyl methanesulfonate caused genotoxicity in Drosophila melanogaster,” International Journal of Medicinal Mushrooms, vol. 13, no. 4, pp. 377–385, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Mizuno, T. Kinoshita, C. Zhuang, H. Ito, and Y. Mayuzumi, “Antitumor-active heteroglycans from niohshimeji mushroom, tricholoma giganteum,” Bioscience, Biotechnology and Biochemistry, vol. 59, no. 4, pp. 568–571, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Firenzuoli, L. Gori, and G. Lombardo, “The medicinal mushroom Agaricus blazei murrill: review of literature and pharmaco-toxicological problems,” Evidence-based Complementary and Alternative Medicine, vol. 5, no. 1, pp. 3–15, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Kozarski, A. Klaus, M. Niksic, D. Jakovljevic, J. P. F. G. Helsper, and L. J. L. D. Van Griensven, “Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus,” Food Chemistry, vol. 129, no. 4, pp. 1667–1675, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Limón-Pacheco and M. E. Gonsebatt, “The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress,” Mutation Research, vol. 674, no. 1-2, pp. 137–147, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Anderson, T.-W. Yu, B. J. Phillips, and P. Schmezer, “The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay,” Mutation Research—Fundamental and Molecular Mechanisms of Mutagenesis, vol. 307, no. 1, pp. 261–271, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. D. W. Fairbairn, P. L. Olive, and K. L. O'Neill, “The comet assay: a comprehensive review,” Mutation Research/Reviews in Genetic Toxicology, vol. 339, no. 1, pp. 37–59, 1995. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Henderson, A. Wolfreys, J. Fedyk, C. Bourner, and S. Windebank, “The ability of the Comet assay to discriminate between genotoxins and cytotoxins,” Mutagenesis, vol. 13, no. 1, pp. 89–94, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Shi, A. E. James, I. F. F. Benzie, and J. A. Buswell, “Genoprotective activity of edible and medicinal mushroom components,” International Journal of Medicinal Mushrooms, vol. 6, pp. 1–14, 2004. View at Google Scholar
  23. G. Aviello, J. M. Canadanovic-Brunet, N. Milic et al., “Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa,” PLOS ONE, vol. 6, no. 5, Article ID e19628, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, “A simple technique for quantitation of low levels of DNA damage in individual cells,” Experimental Cell Research, vol. 175, no. 1, pp. 184–191, 1988. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Oyaizu, “Studies on products of browning reaction prepared from glucose amine,” Japanese Journal of Nutrition, vol. 44, pp. 307–315, 1986. View at Google Scholar
  26. K. Shimada, K. Fujikawa, K. Yahara, and T. Nakamura, “Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion,” Journal of Agricultural and Food Chemistry, vol. 40, no. 6, pp. 945–948, 1992. View at Publisher · View at Google Scholar · View at Scopus
  27. S.-K. Chung, T. Osawa, and S. Kawakishi, “Hydroxyl radical-scavenging effects of spices and scavengers from brown mustard (Brassica nigra),” Bioscience, Biotechnology and Biochemistry, vol. 61, no. 1, pp. 118–123, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. N. V. Savina, N. V. Nikitchenko, T. D. Kuzhir, A. I. Rolevich, S. A. Krasny, and R. I. Goncharova, “The cellular response to oxidatively induced DNA damage and polymorphism of some DNA repair genes associated with clinicopathological features of bladder cancer,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 5710403, 13 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Radaković, N. Đelić, J. Stevanović et al., “Evaluation of the antigenotoxic effects of the royal sun mushroom, Agaricus brasiliensis (Higher basidiomycetes) in human lymphocytes treated with thymol in the comet assay,” International Journal of Medicinal Mushrooms, vol. 17, no. 4, pp. 321–330, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Vasiljevic, L. P. Zivkovic, A. Cabarkapa, V. P. Bajic, N. J. Djelic, and B. M. Spremo-Potparevic, “Cordyceps sinensis: genotoxic potential in human peripheral blood cells and antigenotoxic properties against hydrogen peroxide by comet assay,” Alternative Therapies in Health and Medicine, vol. 22, supplement 2, pp. 24–31, 2016. View at Google Scholar
  31. S. I. R. Franke, D. Prá, B. Erdtmann, J. A. P. Henriques, and J. Da Silva, “Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis,” Mutagenesis, vol. 20, no. 4, pp. 279–283, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Čabarkapa, L. Živković, D. Žukovec et al., “Protective effect of dry olive leaf extract in adrenaline induced DNA damage evaluated using in vitro comet assay with human peripheral leukocytes,” Toxicology in Vitro, vol. 28, no. 3, pp. 451–456, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. A. B. D. Sá-Nakanishi, A. A. Soares, A. L. De Oliveira, J. Fernando Comar, R. M. Peralta, and A. Bracht, “Effects of treating old rats with an aqueous Agaricus blazei extract on oxidative and functional parameters of the brain tissue and brain mitochondria,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 563179, 13 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. A. A. Soares, A. L. De Oliveira, A. B. Sá-Nakanishi et al., “Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats,” BioMed Research International, vol. 2013, Article ID 469180, 12 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Kozarski, A. Klaus, D. Jakovljevic et al., “Antioxidants of edible mushrooms,” Molecules, vol. 20, no. 10, pp. 19489–19525, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. S.-Y. Tsai, H.-L. Tsai, and J.-L. Mau, “Antioxidant properties of Agaricus blazei, Agrocybe cylindracea, and Boletus edulis,” LWT—Food Science and Technology, vol. 40, no. 8, pp. 1392–1402, 2007. View at Publisher · View at Google Scholar
  37. M. A. Hussein, “A convenient mechanism for the free radical scavenging activity of resveratrol,” International Journal of Phytomedicine, vol. 3, no. 4, pp. 459–469, 2011. View at Google Scholar · View at Scopus
  38. G. M. Benhusein, E. Mutch, S. Aburawi, and F. M. Williams, “Genotoxic effect induced by hydrogen peroxide in human hepatoma cells using comet assay,” Libyan Journal of Medicine, vol. 5, no. 1, pp. 1–6, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. A. F. Da Silva, D. Sartori, F. C. MacEdo Jr., L. R. Ribeiro, M. H. P. Fungaro, and M. S. Mantovani, “Effects of β-glucan extracted from Agaricus blazei on the expression of ERCC5, CASP9, and CYP1A1 genes and metabolic profile in HepG2 cells,” Human and Experimental Toxicology, vol. 32, no. 6, pp. 647–654, 2013. View at Publisher · View at Google Scholar · View at Scopus