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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 9028435, 13 pages
https://doi.org/10.1155/2017/9028435
Review Article

Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy

School of Biological Sciences, Nanyang Technological University, Singapore

Correspondence should be addressed to Esther Wong; gs.ude.utn@gnowrehtse

Received 19 March 2017; Accepted 26 April 2017; Published 25 May 2017

Academic Editor: Moh H. Malek

Copyright © 2017 Sijie Tan and Esther Wong. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mitochondria are important bioenergetic and signalling hubs critical for myriad cellular functions and homeostasis. Dysfunction in mitochondria is a central theme in aging and diseases. Mitophagy, a process whereby damaged mitochondria are selectively removed by autophagy, plays a key homeostatic role in mitochondrial quality control. Upregulation of mitophagy has shown to mitigate superfluous mitochondrial accumulation and toxicity to safeguard mitochondrial fitness. Hence, mitophagy is a viable target to promote longevity and prevent age-related pathologies. Current challenge in modulating mitophagy for cellular protection involves identification of physiological ways to activate the pathway. Till date, mitochondrial stress and toxins remain the most potent inducers of mitophagy. Polyphenols have recently been demonstrated to protect mitochondrial health by facilitating mitophagy, thus suggesting the exciting prospect of augmenting mitophagy through dietary intake. In this review, we will first discuss the different surveillance mechanisms responsible for the removal of damaged mitochondrial components, followed by highlighting the transcriptional regulatory mechanisms of mitophagy. Finally, we will review the functional connection between polyphenols and mitophagy and provide insight into the underlying mechanisms that potentially govern polyphenol-induced mitophagy.