Cellular and Molecular Mechanisms of Diabetic Atherosclerosis: Herbal Medicines as a Potential Therapeutic Approach

Table 1

MicroRNA involved in diabetic atherosclerosis.

miR type	Animal model	Mechanism	Target gene	Reference
miR33	STZ-induced diabetic Ldlr−/− mice	Increased macrophages and lipid content	ABCA1	[37]
miR 125b	Type 2 diabetic db/db mice	Increased inflammatory gene expression	SUV39H1	[38]
miR 200	Type 2 diabetic db/db mice	Increased inflammatory gene expression	Zeb1	[39]
miR 504	Type 2 diabetic db/db mice	Vascular smooth muscle phenotype change	Grb10	[40]
miR138	Type 2 diabetic db/db mice	Vascular smooth muscle phenotype change	SIRT1	[41]

ABCA1: ATP-binding cassette transporter A1; SIRT1: silent information regulator 1.