Arsenite Effects on Mitochondrial Bioenergetics in Human and Mouse Primary Hepatocytes Follow a Nonlinear Dose Response

Figure 6

Arsenite induces a primary hepatocyte phenotype that resists oxidant stress. Arsenic and vehicle alone treated (a) mouse and (b) human primary hepatocytes were exposed to a toxic oxidative stress from 100 μM H₂O₂. Cells from both groups were exposed to H₂O₂ at time = 0 and necrosis was determined using SYTOX Green over 72 h following exposure. Data presented as mean ± SD. Significantly different from vehicle treated hepatocytes at the designated time point; . Significantly different from 10 uM arsenic treated hepatocytes at the designated time point: .

(a)

(b)