Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress

<div>Apocynin decreases platelet activation induced by chronic stress. Flow cytometry analyses of (a) GPIIbIIIa activation (JON/A-PE antibody) and (b) P-selectin expression in washed platelets, and percentage of (c) platelet/monocyte, (d) platelet/neuthrophil, and (e) platelet/lymphocyte aggregates in whole blood of control mice (treated with vehicle) and of mice exposed to forced swimming stress with vehicle (FSS) or with Apocynin (FSS + Apocynin). <svg height="8.55521pt" id="M31" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 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Data were analyzed by 2-way ANOVA with repeated measures for main effects of treatment and stimuli, followed by a Bonferroni post hoc analysis.</div>

Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress 