Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome

Figure 2

Clinical state and morphology of the cornea in general anesthesia-induced DES upon premedication or treatment with SkQ1. Corneal status in the rabbits with anesthesia-induced DES premedicated (a) or treated (b) with SkQ1 eye drops. for all values measured in all premedication groups and in 7.5 μM SkQ1 treatment group compared with the values obtained for the control group. (c) Representative microscopic images of hematoxylin and eosin staining of rabbit corneas from different experimental groups. Control animals: normal cornea (А, J). Cornea immediately after 6 h general anesthesia: without premedication (B, C) and after premedication with 0.25 (D, E), 2.5 (F, G), or 7.5 μM (H, I) SkQ1. Cornea after 6 h of general anesthesia on the fourteenth day of treatment with 7.5 μM SkQ1 (K, L). Margins of cornea erosion are shown by red arrowheads; desquamation of superficial epithelial cells is indicated by white arrowheads; prenecrotic and apoptotic changes are indicated by black arrows. For abbreviations see Figure 1. Magnification: ×400; scale bar 50 μm.

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