Oxidative stress and antioxidant activity in the cornea in general anesthesia-induced DES upon premedication with SkQ1. (a) Concentration of MDA in rabbit corneal homogenates after 1–6 h of general anesthesia with or without premedication using 7.5 μM SkQ1. (b)–(f) Total antioxidant activity (b) and activity of SOD (c), GR (d), GPx (e), and GST (f) in corneal extracts after 6 h of general anesthesia with or without premedication using 7.5 μM SkQ1. compared with the values measured in control group before general anesthesia.
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