Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome

Table 2

Pathomorphological characteristics of the cornea in general anesthesia-induced DES.

Corneal compartment	Diagnosis	Parameter	Anesthesia time, h
			Control	1	3	6
Epithelium	Superficial cell desquamation	Incidence, %	0	100	100	100
		MSS	0	2.3 ± 0.5	3.6 ± 0.6	4.3 ± 0.5
	Deep layer cell loss (erosion)	Incidence, %	0	0	100	100
		MSS	0	0	2.0 ± 0.9	4.3 ± 0.6
	Denudation	Incidence, %	0	0	66	100
		MSS	0	0	2.0 ± 1.5	4.0 ± 0.9
	Cell degeneration	Incidence, %	0	0	100	100
		MSS	0	0	3.3 ± 0.6	3.7 ± 0.5
	Signs of apoptosis	Incidence, %	0	0	33	100
		MSS	0	0	0.6 ± 0.9	3.6 ± 0.5
	Reepithelization	Incidence, %	0	0	0	0
		MSS	0	0	0	0
Stroma	Edema	Incidence, %	0	0	0	0
		MSS	0	0	0	0
	Inflammatory infiltration	Incidence, %	0	0	0	0
		MSS	0	0	0	0
	Neovascularization	Incidence, %	0	0	0	0
		MSS	0	0	0	0
Endothelium	Vacuolization	Incidence, %	0	0	0	0
		MSS	0	0	0	0
	Cell loss	Incidence, %	0	0	0	0
		MSS	0	0	0	0

Incidence and mean severity scores (MSS) were determined as described in Materials and Methods. compared with control.