Oxidative Medicine and Cellular Longevity

Research Article

UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families

Table 1

The contents (μg/g) of alkaloids in investigated plant species.
Plant speciesCompound
AllocryptopineBerberineChelerythrineChelidonineColumbamineCoptisineCorydalineCorydamineCorydineCryptopineN,N-Dimethyl-hernovineFumarophycineGlaucineJatrorrhizineMethyl-corypalmineMethyl-hernovineProtopineSanguinarineTetrahydropalmatine
Berberis thunbergii−6358.4 ± 4.2−−++−−−−−+/−−−−−−−−−
Chelidonium majus+++5366.6 ± 4.3+++51,040.0 ± 1.8−−−−−+++++−−−−−11,660.6 ± 13.67925.8 ± 3.3−
Corydalis cava−−−−−++++−++−++−−−−−1764.0 ± 0.769.0 ± 0.1+/−
Dicentra spectabilis−−−−−−−−−−−−−−−−11,899.6 ± 8.61105.6 ± 1.0−
Fumaria officinalis−−−650.0 ± 0.5−−−+/−−−−+/−−−+/−−3726.6 ± 0.6125.4 ± 0.2−
Glaucium flavum−−−−−−−−−−++−+++−−+/−4990.0 ± 1.3407.4 ± 0.9−
Macleaya cordata+++1401.4 ± 2.4−−−−−−−−−−−−−−54,636.4 ± 2.61835.0 ± 4.3−
Mahonia aquifolium−3344.6 ± 3.7−−−−−−−−++−−++−−−−−
Meconopsis cambrica−−−−−−−−−−+−−−−−74.4 ± 0.4−−
Comparisons with chemical standard have been made; without ∗ indicates tentative assignment based on UV-Vis and MS/MS profile. −: not detected; +/−: tentatively detected, <5% based on the peak area recorded at 270 nm for all identified; +: <15% based on peak area recorded at 270 nm for all identified, ++: 15–30% based on the peak area recorded at 270 nm for all identified; +++: >30% based on the peak area recorded at 270 nm for all identified.