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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 9427583, 10 pages
https://doi.org/10.1155/2017/9427583
Research Article

Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin

1Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea
2Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan 570-750, Republic of Korea
3Department of Life Science, Okayama University, Okayama 770-0005, Japan

Correspondence should be addressed to Hun Taeg Chung

Received 22 December 2016; Revised 27 March 2017; Accepted 11 April 2017; Published 18 May 2017

Academic Editor: Takuya Akiyama

Copyright © 2017 Yingqing Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3′-untranslated regions of mRNAs. Here, we utilized pterostilbene 4′-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement. TTP expression was increased in 4-PG dose- and time-dependent manners in RAW264.7 cells. The production of proinflammatory cytokine, such as TNF-α, was reduced by 4-PG in vitro. To investigate the role of TTP in the anti-inflammatory effects of 4-PG, we used DSS-induced colitis in TTP WT and KO mice as models. The expression levels of TTP and proinflammatory cytokines were determined in serum and colon tissue. 4-PG increased the expression of TTP while suppressing proinflammatory cytokines both in vitro and in vivo. These findings suggest that treatment with 4-PG mediates the anti-inflammatory effects of 4-PG on DSS-induced colitis via enhancing TTP expression.