Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats

Table 2

Effect of Roselle-Olive combination on some serum biochemical parameters in L-NAME-induced hypertensive rats.

Groups	ALT (U/l)	AST (U/l)	γ-GT (U/l)	Urea (mg/dl)	Creatinine (g/dl)	Triglycerides (mg/dl)	Cholesterol (mg/dl)	HDL (mg/dl)	LDL (mg/dl)
Group 1	35.1 ± 2.86^ǂ	67.3 ± 3.08^ǂ	6.2 ± 0.39^ǂ	37.6 ± 2.60^ǂ	0.5 ± 0.04^ǂ	78.6 ± 3.09^ǂ	67.9 ± 3.14^ǂ	47.6 ± 3.16^ǂ	10.5 ± 0.77^ǂ
Group 2	95.4 ± 4.35	117.9 ± 4.32	13.4 ± 1.06	63.9 ± 3.58	0.9 ± 0.09	105.0 ± 4.47	81.7 ± 3.35	27.3 ± 1.61	25.7 ± 1.97
Group 3	50.5 ± 3.38^ǂ	83.3 ± 3.09^ǂ	12.4 ± 0.61	78.2 ± 3.09^ǂ	0.9 ± 0.06	94.9 ± 3.08	73.9 ± 3.24	23.1 ± 1.85	22.4 ± 1.60
Group 4	60.4 ± 1.55^ǂ	113.3 ± 5.84	7.9 ± 0.64^ǂ	35.6 ± 2.42^ǂ	1.0 ± 0.09	75.0 ± 3.77^ǂ	64.4 ± 3.47^ǂ	42.6 ± 2.41^ǂ	8.3 ± 0.90^ǂ
Group 5	52.3 ± 3.54^ǂ	100.9 ± 5.60	8.5 ± 0.61^ǂ	34.8 ± 2.69^ǂ	0.9 ± 0.08	83.1 ± 3.61^ǂ	64.6 ± 3.80^ǂ	55.4 ± 1.00^ǂ	9.7 ± 0.62^ǂ
Group 6	53.4 ± 2.59^ǂ	107.1 ± 4.50	5.0 ± 0.52^ǂ	33.2 ± 0.79^ǂ	0.9 ± 0.14	82.7 ± 2.62^ǂ	63.9 ± 3.12^ǂ	54.1 ± 1.45^ǂ	8.5 ± 0.36^ǂ

Group 1: normal control; group 2: hypertensive control (L-NAME 50 mg/kg); group 3: L-NAME + lisinopril (10 mg/kg); group 4: L-NAME + Roselle-Olive (500 mg/kg); group 5: L-NAME + Roselle-Olive (250 mg/kg); group 6: L-NAME + Roselle-Olive (125 mg/kg). Values are expressed as mean ± SE (). , statistically significant from the normal control group at the corresponding time. , statistically significant from the hypertensive control group at the corresponding time.