Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats

Table 7

Tail length, tail intensity, and tail moment measured with Comet assay in the kidney of rats treated with L-NAME and protective influence of Roselle-Olive combination.

Groups	Comet %	Head diameter (μm)	Tail length (μm)	% DNA in tail	Tail moment
Group 1	9	38.7 ± 3.5^ǂ	4.9 ± 1.2^ǂ	26.9 ± 4.2^ǂ	1.64 ± 0.35^ǂ
Group 2	26.2	22.9 ± 2.9	6.87 ± 2.3	11.39 ± 1.7	2.87 ± 0.67
Group 3	19.4	32.1 ± 3.4^ǂ	5.62 ± 1.9^ǂ	13.36 ± 1.3 ^ǂ	1.82 ± 0.72^ǂ
Group 4	10.6	29.1 ± 2.9^ǂ	4.2 ± 1.9^ǂ	16.3 ± 2.6^ǂ	1.45 ± 0.38^ǂ
Group 5	11.6	31.8 ± 2.8^ǂ	4.41 ± 1.6^ǂ	14.4 ± 1.9	1.82 ± 0.82^ǂ
Group 6	23.8	30.01 ± 2.5^ǂ	4.2 ± 1.3^ǂ	12.7 ± 1.2	1.6 ± 0.46^ǂ

Group 1: normal control; group 2: hypertensive control (L-NAME 50 mg/kg); group 3: L-NAME + lisinopril (10 mg/kg); group 4: L-NAME + Roselle-Olive (500 mg/kg); group 5: L-NAME + Roselle-Olive (250 mg/kg); group 6: L-NAME + Roselle-Olive (125 mg/kg). Values are expressed as the mean ± SE. n = number of rats. , statistically significant from the normal control group at the corresponding time. , statistically significant from the hypertensive control group at the corresponding time.