Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats

Table 8

Tail length, tail intensity, and tail moment measured with Comet assay in the heart of rats treated with L-NAME and protective influence of Roselle-Olive combination.

Groups	Comet %	Head diameter (μm)	Tail length (μm)	% DNA in tail	Tail moment
Group 1	8	20.09 ± 3.1^ǂ	5.2 ± 1.2^ǂ	23.2 ± 2.8^ǂ	1.31 ± 0.44^ǂ
Group 2	24	14.3 ± 0.98	6.17 ± 2.2	30.6 ± 2.6	2.02 ± 0.89
Group 3	21.3	17.9 ± 1.6^ǂ	5.9 ± 1.4	22.3 ± 3.3^ǂ	1.82 ± 0.28^ǂ
Group 4	19.7	17.2 ± 1.3^ǂ	6.42 ± 1.9	23.3 ± 2.3^ǂ	1.5 ± 0.56^ǂ
Group 5	20.3	17.8 ± 1.2^ǂ	5.81 ± 1.4^ǂ	31.5 ± 2.8	1.89 ± 0.58
Group 6	22	14.9 ± 1.4	6.12 ± 1.5	31.5 ± 3.4	1.9 ± 0.72

Group 1: normal control; group 2: hypertensive control (L-NAME 50 mg/kg); group 3: L-NAME + lisinopril (10 mg/kg); group 4: L-NAME + Roselle-Olive (500 mg/kg); group 5: L-NAME + Roselle-Olive (250 mg/kg); group 6: L-NAME + Roselle-Olive (125 mg/kg). Values are expressed as the mean ± SE. n = number of rats. , statistically significant from the normal control group at the corresponding time. , statistically significant from the hypertensive control group at the corresponding time.