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Oxidative Medicine and Cellular Longevity
Volume 2017 (2017), Article ID 9536148, 12 pages
Research Article

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage

1Department of Pharmacy, University of Pisa, Pisa, Italy
2Interdepartmental Research Center “Nutraceuticals and Food for Health”, University of Pisa, Pisa, Italy

Correspondence should be addressed to Eleonora Da Pozzo; ti.ipinu@ozzopad.aronoele

Received 16 November 2016; Revised 6 February 2017; Accepted 28 February 2017; Published 12 March 2017

Academic Editor: Victor M. Victor

Copyright © 2017 Eleonora Da Pozzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined. The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders. Very recently, beneficial effects of naringenin have been demonstrated in old rats. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated. For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. These results suggested that naringenin has antiaging effects on myocardial cells.