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Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 9715898, 8 pages
Research Article

Assessing Free-Radical-Mediated DNA Damage during Cardiac Surgery: 8-Oxo-7,8-dihydro-2′-deoxyguanosine as a Putative Biomarker

1Centro Cardiologico Monzino, IRCCS, Milan, Italy
2Dipartimento di Chirurgia Cardiaca, IRCCS Policlinico San Donato, Milan, Italy

Correspondence should be addressed to Benedetta Porro; ti.mfcc@orrop.attedeneb

Received 3 March 2017; Accepted 9 April 2017; Published 4 June 2017

Academic Editor: Michael Bukrinsky

Copyright © 2017 Linda Turnu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

8-oxodG method validation procedures. Supplemental Table 1. Mobile phase gradient. Supplemental Table 2. Imprecision, LLOQ and LOD of the LC-MS/MS method. Supplemental Table 3. Matrix effect, recovery and process efficiency data for 8-oxodG in urine. Supplemental Table 4. Stability of 8-oxodG in urine.

  1. Supplementary material