Myricitrin Modulates NADPH Oxidase-Dependent ROS Production to Inhibit Endotoxin-Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47^phox Pathways

Figure 9

Effects of myricitrin on histopathological changes in the lung tissues of the mice with LPS-induced acute lung injury (ALI). Mice received a single dose of intratracheal instillation of 50 μl saline with or without (5 mg/kg) LPS, and some of LPS-exposed mice were pretreated with myricitrin (120 mg/kg) or dexamethasone (0.5 mg/kg) via penis vein injection for 4 h. Twelve hours after LPS challenge, mice were euthanized with diethyl ether. The whole lung tissue of mice was primed with paraformaldehyde. The lungs from each group were processed for histological evaluation at 12 h after LPS challenge. (a) Control group; (b) LPS (5 mg/kg) group; (c) dexamethasone (0.5 mg/kg) + LPS (5 mg/kg); (d) myricitrin (0.5 mg/kg) + LPS (5 mg/kg). Representative histological changes of lungs obtained from mice of different groups are shown here (hematoxylin and eosin staining, magnification: 400x).

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