The hemodynamic measurements after MI/R in Ctrl and DM rats.
Parameters
Group
Baseline
Is0
Is30
Rep30
Rep120
HR (bpm)
Ctrl + I/R
325.5 ± 19.8
305.2 ± 17.3
289.7 ± 13.1
289.3 ± 17.3
277.1 ± 10.6
Ctrl + I/R + BAY
312.7 ± 16.8
277.3 ± 21.3
277.7 ± 13.9
283.3 ± 15.7
285.0 ± 14.6
DM + I/R
303.5 ± 27.0&&
246.2 ± 22.3&&
237.3 ± 17.4&&
239.5 ± 27.7&&
250.5 ± 32.2&&
DM + I/R + BAY
307.2 ± 8.8
252.2 ± 13.6
262.2 ± 8.4
275.7 ± 10.2$$
282.3 ± 9.4$$
MAP (mmHg)
Ctrl + I/R
99.7 ± 10.2
70.5 ± 10.8
77.7 ± 9.2
76.7 ± 9.2
73.5 ± 11.8
Ctrl + I/R + BAY
87.7 ± 10.7
61.5 ± 11.0
65.7 ± 5.3
72.3 ± 6.3
76.5 ± 4.4
DM + I/R
91.5 ± 3.7
74.5 ± 12.8
75 ± 5.4
72.3 ± 5.9
63.7 ± 6.9
DM + I/R + BAY
92.2 ± 2.8
69.0 ± 5.3
75.7 ± 8.4
76.5 ± 6.9
81.3 ± 9.6$
RPP (min. mmHg 103)
Ctrl + I/R
34.7 ± 5.4
24.5 ± 3.6
25.7 ± 4.6
25.4 ± 6.4
22.4 ± 4.3
Ctrl + I/R + BAY
29.5 ± 5.5
18.3 ± 2.5##
20.0 ± 2.4##
21.7 ± 2.3
22.6 ± 2.6
DM + I/R
28.9 ± 4.3&
19.8 ± 3.4&
18.8 ± 1.6&&
19.0 ± 2.3&&
17.1 ± 2.6
DM + I/R + BAY
29.6 ± 1.9
18.4 ± 0.9
20.6 + 2.4
24.3 ± 2.1
24.0 ± 3.0$$
The data are expressed as the mean ± SD. . and versus respective baseline; ## versus the control I/R group; and versus the control I/R group; $ and $$ versus the DM + I/R group. Ctrl + I/R and DM + I/R: nondiabetic and diabetic rats were subjected to 30 min ischemia followed by 2 h reperfusion. Ctrl + I/R + BAY and DM + I/R + BAY: nondiabetic and diabetic rats were subjected to 30 min ischemia followed by 2 h reperfusion and were, respectively, given the inflammasome inhibitor BAY11-7082 10 min before reperfusion by intraperitoneal injection.
