Table 2: The hemodynamic measurements after MI/R in Ctrl and DM rats.

ParametersGroupBaselineIs0Is30Rep30Rep120

HR (bpm)Ctrl + I/R325.5 ± 19.8305.2 ± 17.3289.7 ± 13.1289.3 ± 17.3277.1 ± 10.6
Ctrl + I/R + BAY312.7 ± 16.8277.3 ± 21.3277.7 ± 13.9283.3 ± 15.7285.0 ± 14.6
DM + I/R303.5 ± 27.0&&246.2 ± 22.3&&237.3 ± 17.4&&239.5 ± 27.7&&250.5 ± 32.2&&
DM + I/R + BAY307.2 ± 8.8252.2 ± 13.6262.2 ± 8.4275.7 ± 10.2$$282.3 ± 9.4$$
MAP (mmHg)Ctrl + I/R99.7 ± 10.270.5 ± 10.877.7 ± 9.276.7 ± 9.273.5 ± 11.8
Ctrl + I/R + BAY87.7 ± 10.761.5 ± 11.065.7 ± 5.372.3 ± 6.376.5 ± 4.4
DM + I/R91.5 ± 3.774.5 ± 12.875 ± 5.472.3 ± 5.963.7 ± 6.9
DM + I/R + BAY92.2 ± 2.869.0 ± 5.375.7 ± 8.476.5 ± 6.981.3 ± 9.6$
RPP (min. mmHg 103)Ctrl + I/R34.7 ± 5.424.5 ± 3.625.7 ± 4.625.4 ± 6.422.4 ± 4.3
Ctrl + I/R + BAY29.5 ± 5.518.3 ± 2.5##20.0 ± 2.4##21.7 ± 2.322.6 ± 2.6
DM + I/R28.9 ± 4.3&19.8 ± 3.4&18.8 ± 1.6&&19.0 ± 2.3&&17.1 ± 2.6
DM + I/R + BAY29.6 ± 1.918.4 ± 0.920.6 + 2.424.3 ± 2.124.0 ± 3.0$$

The data are expressed as the mean ± SD. . and versus respective baseline; ## versus the control I/R group; and versus the control I/R group; $ and $$ versus the DM + I/R group. Ctrl + I/R and DM + I/R: nondiabetic and diabetic rats were subjected to 30 min ischemia followed by 2 h reperfusion. Ctrl + I/R + BAY and DM + I/R + BAY: nondiabetic and diabetic rats were subjected to 30 min ischemia followed by 2 h reperfusion and were, respectively, given the inflammasome inhibitor BAY11-7082 10 min before reperfusion by intraperitoneal injection.