Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study

Figure 2

DNA damage of 30 PVHA, before (M0) and after (M1) cART initiation. (a) → In blue: patients analyzed together; in red: patients separated into initial CD4+ T groups. G1- CD4+ T counts <500, ; G2- CD4+ T >500 cells/mL (considering the counts in M0), . PLWHA: people living with HIV/AIDS; cART: combined antiretroviral therapy. BAS: basal condition (without enzymes); END: blades treated with the endonuclease III enzyme (thymine glycol -DNA glycosylase); FPG: blades treated with the formanodipirimidina-DNA glycosylase enzyme. Statistical tests: Gamma Distribution for Bas-ti and FPG-tm; ANOVA with post hoc Tukey tests for the other variables. . Units of measure: ti (tail intensity) and tm (tail moment). (b) → This HIV-infected subject presented initial CD4+ T counts >500 cells/mL, and the figure shows the enzymatic (END [A, B], FPG [C, D]) and basal conditions (BAS [E, F]), before (A, C, E) and after (B, D, F) cART initiation.

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