Coenzyme Q10 Regulates Antioxidative Stress and Autophagy in Acute Myocardial Ischemia-Reperfusion Injury

Table 1

Effect of CQ10 on the change of SOD, GSH, TBARS, GPx, and GR in rat myocardial tissue with acute myocardial ischemia-reperfusion injury.

	AMI/R				CQ10 + AMI/R
	Sham	2 h	24 h	72 h	Sham	2 h	24 h	72 h
SOD (U/mg protein)	26.89 ± 2.42	20.96 ± 2.23	15.13 ± 1.89	10.76 ± 1.92	27.29 ± 2.14	22.25 ± 2.35	18.63 ± 2.41^&	14.31 ± 1.98^#
GSH (μmol/mg protein)	5.82 ± 0.54	4.42 ± 0.28	3.13 ± 0.33	2.64 ± 0.32	5.98 ± 0.37	5.38 ± 0.43	4.27 ± 0.37^&	3.47 ± 0.41^#
TBARS (nmol/mg protein)	1.33 ± 0.09	2.74 ± 0.14	3.94 ± 0.29	5.38 ± 0.37	1.29 ± 0.12	2.38 ± 0.19	3.19 ± 0.31^&	4.57 ± 0.42^#
GPx (μmol/protein)	7.41 ± 0.64	5.43 ± 0.52	3.12 ± 0.33	2.14 ± 0.23	7.38 ± 0.56	6.11 ± 0.44	4.57 ± 0.42^&	3.25 ± 0.31^#
GR (μmol/protein)	5.14 ± 0.31	3.28 ± 0.34	2.11 ± 0.27	1.89 ± 0.21	5.23 ± 0.29	4.56 ± 0.38	3.75 ± 0.42^&	3.01 ± 0.44^#

CQ10 increased antioxidation (SOD, GSH, GPx, and GR) and reduced oxidation (TBARS) in rats with acute myocardial ischemia-reperfusion injury at same time point. SOD: superoxide dismutase; GSH: glutathione; TBARS: thiobarbituric acid reactive substances; GPx: glutathione peroxidase; GR: glutathione reductase. compared with 2 h in AMI/R group, ; ^& compared with 24 h in AMI/R group, ; ^# compared with 72 h in AMI/R group, .