Research Article

Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause

Table 1

Effect of M. citrifolia leaf extract on the neurological score of ovariectomized rats which were subjected to a 90-minute ischemic-reperfusion injury at the right middle cerebral artery at 24 hours after the induction of ischemic-reperfusion injury (/group). value < 0.05, value < 0.05, and p < 0.001, respectively, compared to OVX + sham operation. value < 0.05, value < 0.01, and value < 0.001, respectively, compared to OVX + MCAO.

ParameterSpontaneous activitySymmetry in the movement of the four limbsForepaw outstretchingClimbingResponse to vibrissal touchBody proprioception

OVX + sham operation3.00 ± 0.003.00 ± 0.003.00 ± 0.003.00 ± 0.003.00 ± 0.003.00 ± 0.00
OVX + vehicle + MCAO2.33 ± 0.672.00 ± 0.171.00 ± 0.582.00 ± 0.001.33 ± 0.331.00 ± 0.00
OVX + positive + MCAO2.00 ± 0.581.67 ± 0.002.67 ± 0.332.00 ± 0.582.67 ± 0.332.33 ± 0.67
OVX + M. citrifolia (2 mg/kg BW) + MCAO2.67 ± 0.332.00 ± 0.332.67 ± 0.332.67 ± 0.333.00 ± 0.003.00 ± 0.00
OVX + M. citrifolia (10 mg/kg BW) + MCAO1.75 ± 0.752.00 ± 0.712.00 ± 0.712.50 ± 0.292.25 ± 0.482.50 ± 0.29
OVX + M. citrifolia (50 mg/kg BW) + MCAO2.75 ± 0.252.50 ± 0.292.75 ± 0.252.50 ± 0.292.75 ± 0.252.75 ± 0.25