Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause

Table 2

Effect of M. citrifolia leaf extract on the oxidative stress status including the level of malondialdehyde (MDA) and the activities of main scavenger enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the cerebral cortex of OVX rats which were subjected to MCAO (/group). value < 0.001 compared to OVX + sham operation group. value < 0.05 and value < 0.001, respectively, compared to OVX + MCAO group.

Treatment	MDA (nm/mg protein)	SOD (unit/mg protein)	CAT (unit/mg protein)	GPx (unit/mg protein)
OVX + sham operation	0.97 ± 0.16	25.13 ± 8.20	25.45 ± 8.88	3.45 ± 0.92
OVX + MCAO	2.96 ± 0.30^aaa	14.27 ± 2.65	18.03 ± 5.98	1.96 ± 0.29
OVX + MCAO + genistein	2.79 ± 0.06	13.86 ± 1.14	6.42 ± 0.63	2.68 ± 0.76
OVX + MCAO + M. citrifolia (2 mg/kg)	2.51 ± 0.72	34.65 ± 6.83	22.26 ± 0.80	6.00 ± 1.03
OVX + MCAO + M. citrifolia (10 mg/kg)	2.58 ± 0.35	21.85 ± 3.14	25.54 ± 5.83	4.24 ± 0.24
OVX + MCAO + M. citrifolia (50 mg/kg)	0.24 ± 0.05	25.22 ± 5.54	22.82 ± 4.30	4.76 ± 0.11