Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression
Effects of postischemia-reperfusion (I/R) treatment with TMZ on renal function at different time points. Renal I/R injury produced a significant increase in serum BUN (a) and creatinine levels (b), which were significantly attenuated in the TMZS group at 24 h after reperfusion. The elevated serum BUN and creatinine levels returned to their respective baseline values in all groups at 5 d after renal I/R injury and were at similar levels at 8 w after renal I/R injury without any intergroup differences. TMZ = trimetazidine; BUN = blood urea nitrogen. Sham = rats not underwent I/R; IRC = rats underwent ischemia (45 min)-reperfusion (24 h, 5 d, and 8 w); TMZS = rats treated with TMZ (3 mg/kg) upon reperfusion; TMZD = rats treated with TMZ (3 mg/kg) once daily for 5 d or 8 w starting upon reperfusion. versus sham, versus IRC.