Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression

Figure 3

Effects of postischemia-reperfusion (I/R) treatment with TMZ on renal tubular cell necrosis. Representative histology of renal tubules after and PAS staining. Compared to the sham groups, I/R injury resulted in significant necrosis in the IRC groups at 24 h and 5 d after I/R injury. TMZ significantly attenuated cell necrosis compared to the IRC groups at 24 h and 5 d after I/R injury. At 8 w after I/R injury, PAS staining of renal tissues demonstrated almost full recovery of histopathologic findings in the IRC and the TMZ-treated groups, without intergroup differences. TMZ = trimetazidine; PAS = periodic acid-Schiff. Sham = rats not underwent I/R; IRC = rats underwent ischemia (45 min)-reperfusion (24 h, 5 d, and 8 w); TMZ^S = rats treated with TMZ (3 mg/kg) upon reperfusion; TMZ^D = rats treated with TMZ (3 mg/kg) once daily for 5 d or 8 w starting upon reperfusion.