Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression
Effect of postischemia-reperfusion (I/R) treatment with TMZ on renal tubulointerstitial fibrosis. Representative histology (a) of renal tubules after Masson’s trichrome staining and quantitative analysis (b) of tubulointerstitial fibrosis. Renal fibrosis was significantly more prominent in the IRC and TMZ-treated groups compared to that in the sham group at 8 w after renal I/R injury, without any intergroup differences between the IRC and TMZ-treated groups. TMZ = trimetazidine. Sham = rats not underwent I/R; IRC = rats underwent ischemia (45 min)-reperfusion (8 w); TMZS = rats treated with TMZ (3 mg/kg) upon reperfusion; TMZD = rats treated with TMZ (3 mg/kg) once daily for 8 w starting upon reperfusion. versus sham.