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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 1347969, 8 pages
https://doi.org/10.1155/2018/1347969
Review Article

Bach1: Function, Regulation, and Involvement in Disease

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

Correspondence should be addressed to Dan Meng; nc.ude.naduf@gnemd

Received 23 May 2018; Accepted 12 September 2018; Published 2 October 2018

Academic Editor: Kum Kum Khanna

Copyright © 2018 Xinyue Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes. It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic angiogenesis and promote breast cancer metastasis. This review summarizes how Bach1 controls these and other cellular and physiological and pathological processes. Bach1 expression and function differ between different cell types. Thus, therapies designed to manipulate Bach1 expression will need to be tightly controlled and tailored for each specific disease state or cell type.