Bach1: Function, Regulation, and Involvement in Disease

Figure 3

Relations between Bach1 and angiogenesis. Bach1 suppresses angiogenesis through different mechanisms. Bach1 represses the expression of HO-1, which has been shown to upregulate the expression of proangiogenic molecules (e.g., VEGF) and promote neovascularization. Bach1 overexpression also enhances the production of ROS from the mitochondria of endothelial cells, which leads to EC apoptosis and inhibits angiogenesis. Besides, Bach1 functions as a competitive inhibitor of β-catenin/TCF4 binding, recruits HDAC1 to the promoter of Wnt target genes, thereby reducing the expression of proangiogenic cytokines, such as VEGF and IL-8, and suppresses angiogenesis.