Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway

Table 1

Effects on body weight, liver weight, hepatic As content, and urinary As content in the absence (NaAsO₂) and presence of CA (CA + NaAsO₂) in mice.

Parameters	Gr I	Gr II	Gr III	Gr IV
Body weight (g)	28.16 ± 3.11	21.77 ± 2.08^#	26.08 ± 3.01	26.92 ± 3.33
Liver weight (g)	1.24 ± 0.21	1.15 ± 7.29	1.17 ± 0.13	1.22 ± 0.25
Liver As (μg/g of tissue)	0.06 ± .0001	0.51 ± 0.04^#	0.35 ± 0.04	0.32 ± 0.02
Urinary As (μg/g of creatinine)	2.34 ± 0.31	19.65 ± 2.17^#	23.67 ± 2.98	26.01 ± 3.22

Values are expressed as mean ± SD (). ^#Values differ significantly from normal control (). Values differ significantly from NaAsO₂ control (). Values differ significantly from NaAsO₂ control (). Gr I: normal control; Gr II: toxic control; Gr III: CA (10 mg/kg) + NaAsO₂ (10 mg/kg); Gr IV: CA (20 mg/kg) + NaAsO₂ (10 mg/kg).