Research Article

Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children

Table 1

Basic clinical data and kidney function parameters depending on thrombomodulin concertation in the investigated group of 59 patients.

ParameterThrombomodulin value
<2xULN ()≥2xULN ()

Age (years)10.5 (5.0; 16.0)12.1 (9.1; 15.3)0.277
Male sex (n)17 (65.4%)19 (57.5%)0.599
Height (z-score)−0.35 (−1.77; 0.07)−1.34 (−2.38; −0.27)0.097
Body mass (z-score)−0.84 (1.30; 0.11)−1.06 (−2.55; −0.01)0.320
BMI (kg/m2)16.5 (15.8; 18.6)16.8 (14.9; 20.1)0.970
BMI (z-score)−0.62 (−1.11; 0.53)−0.66 (−1.45; 0.44)0.903
Creatinine (μmol/l)110.8 (93.8; 179.3)403.0 (283.3; 725.3)<0.001
Cystatin (mg/l)1.58 (1.25; 2.06)4.21 (3.05; 5.82)<0.001
eGFR Filler (ml/min/1.73 m2)55.2 (38.8; 72.0)18.4 (12.0; 26.2)<0.001
Microalbuminuria (mg/l)18.0 (10,7; 63.0)99.5 (24.5; 423.0)0.005

Values presented as median (25th–75th percentile). Mann–Whitney U test. ULN: upper limit of normal; BMI: body mass index; eGFR: estimated glomerular filtration rate.