Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children

Table 3

Oxidative stress and endothelial dysfunction parameters depending on thrombomodulin concentration in the investigated group of 59 patients.

Parameter	Thrombomodulin		value
	<2xULN ()	≥2xULN ()
vWF (%)	87.8 (78.8; 93.3)	90.2 (82.8; 96.7)	0.521
Carbonyl groups (nmol/mg)	1.18 (0.61; 1.89)	1.36 (0.82; 2.17)	0.634
ADMA (μmol/l)	0.94 (0.75; 1.16)	1.23 (0.90; 1.40)	0.029
BNP (pg/ml)	4.43 (1.00; 15.39)	15.63 (5.88; 24.23)	0.021
oxLDL (U/l)	80.6 (67.4; 91.9)	88.6 (78.7; 106.9)	0.033
hsCRP (ng/ml)	373.2 (132.6; 736.1)	310.7 (145.6; 878.1)	0.535
ICAM-1 (ng/ml)	373.2 (132.6; 736.1)	323.6 (290.3; 384.4)	0.977
Fibrinogen (g/l)	3.5 (2.5; 4.4)	3.3 (2.4; 4.4)	0.856

Values presented as median (25th–75th percentile). Mann–Whitney U test. ULN: upper limit of normal; vWF: von Willebrand factor; ADMA: asymmetric dimethylarginine; BNP: brain natriuretic peptide; oxLDL: oxidized low-density lipoprotein; hsCRP: high sensitive C-reactive protein; ICAM-1: intercellular adhesion molecule-1.