Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.

Figure 11

Immunohistochemical analysis for Ki-67 and BrdU of the gastric mucosa of the rats subjected to induction of chronic ulcer by 30% acetic acid. Animals were treated orally with 0.9% NaCl solution (LC, injured control), ranitidine (60 mg/kg), or ethanolic extract of the leaves of Spondias mombin (SmEE, 100 mg/kg) for 14 days. The filled arrow indicates the absence of the epithelial layer (ulcer area internal), and the dashed arrow indicates epithelial layer remaining (ulcer edge). Microphotographs depict the immunoreactivity for Ki-67 and BrdU in the groups, magnification 200x.