Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.

Table 5

Effect of the oral pretreatment with ethanolic extract of the leaves of Spondias mombin (SmEE) on TNF-α and NO production in gastric lesions induced by HCl/ethanol in mice.

Pretreatment	HCl/ethanol-induced ulcer
	TNF-α production (pg/mL of tissue)	NO production (μmol/g of tissue)
Injured control (LC)	2.32 ± 0.04	2.78 ± 0.01
Lansoprazole (30 mg/kg)	2.02 ± 0.02	4.47 ± 0.00
SmEE (50 mg/kg)	0.89 ± 0.00	20.30 ± 0.19
SmEE (100 mg/kg)	1.08 ± 0.02	11.41 ± 0.18
SmEE (200 mg/kg)	0.66 ± 0.02	4.49 ± 0.08

The results are expressed as the mean ± SEM (n = 5–7/group). ANOVA followed by Dunnett’s multiple comparisons test, .