Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 4

Research Article

Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells

Figure 4

IBC directly binds and inactivates TrxR1 in PC-3 cells. (a) The activity of the TrxR1 enzyme. (b) The TrxR1 expression was determined by Western blotting after knockdown with siRNAs for 12 h. (c) Knockdown of TrxR1 in PC-3 cells significantly increased the ROS levels (d) and apoptotic cells. All data are presented as mean ± S.D. and compared to the control group.

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