Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 4

Research Article

Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells

Figure 4

IBC directly binds and inactivates TrxR1 in PC-3 cells. (a) The activity of the TrxR1 enzyme. (b) The TrxR1 expression was determined by Western blotting after knockdown with siRNAs for 12 h. (c) Knockdown of TrxR1 in PC-3 cells significantly increased the ROS levels (d) and apoptotic cells. All data are presented as mean ± S.D. and compared to the control group.
(a)
(b)
(c)
(d)

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.