The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro

Figure 3

DAU attenuated tau phosphorylation in both N2a/APP cells and HEK293/Tau cells. Levels of phosphorylated tau and total tau in N2a/WT and N2a/APP cells (a, b) and in HEK293/Tau cells (c, d) as determined by Western blot analysis. β-Actin was used as a loading control. . Data show the mean ± SEM. compared to N2a/WT cells, and compared to untreated N2a/APP cells, and and compared to untreated HEK293/Tau cells.

(a)

(b)

(c)

(d)