Simvastatin Treatment Upregulates HO-1 in Patients with Abdominal Aortic Aneurysm but Independently of Nrf2
Table 2
Patient characteristic.
Nonstatin
Simvastatin (20 or 40 mg/day)
value
Age (range)
70 (50–80)
66 (50–80)
0.48
AAA diameter (mm) (range)
55.0 (49.0–102.0)
56.0 (49.0–120.0)
0.70
Body mass index (kg/m2) (range)
25.62 (21.97–37.55)
25.95 (20–34.6)
0.80
Coronary artery disease
7/14 (50%)
7/28 (25%)
0.31
Cerebrovascular artery disease
7/14 (50%)
4/28 (14%)
0.77
Hypertension
13/14 (93%)
14/28 (50%)
0.28
Peripheral artery disease
2/14 (14%)
7/28 (25%)
0.20
Diabetes
2/14 (14%)
4/28 (14%)
0.34
Nicotine
8/14 (57%)
11/28 (39%)
0.80
CRP (mg/dl) median (range)
0.40 (0.04–3.0)
0.26 (0.06–9.45)
0.75
Cholesterol (mg/ml) median (range)
240 (143.0–323.0)
206.5 (110.0–300.0)
0.009
HDL (mg/ml) median (range)
46.0 (32.0–68.0)
47.0 (29.0–75.0)
0.61
LDL (mg/dl) median (range)
159.0 (79.2–218.0)
117.3 (56.0–195.0)
0.007
Creatinine (mg/dl) median (range)
1.18 (0.76–1.48)
1.045 (0.78–1.60)
0.45
Hematocrit median (range)
40.9 (30.10–47.30)
40.75 (30.0–51.3)
0.98
Fibrinogen (mg/dl) median (range)
384.0 (240–557.0)
359.0 (213.0–650.0)
0.67
Leukocytes (mln/ml) median (range)
8.45 (6.55–11.60)
8.0 (5.1–13.0)
0.18
Lymphocytes (%) median (range)
22.8 (12.2–41.1)
24.95 (9.7–45.3)
0.82
Monocytes (%) median (range)
8.7 (5.4–14.2)
7.7 (4.5–14.8)
0.07
Neutrophils (%) median (range)
63.10 (46.3–81.6)
64.20 (44.50–82.30)
0.52
Data are presented as frequencies or median (minimum–maximum). Statistical significance for binary variables was assessed using generalized linear models, while metric values were analyzed using linear mixed regression models.
