Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown
Curcumin decreased ROS levels induced by the knockdown of dUCH in eye imaginal discs. Detection of ROS levels in third instar larval eye imaginal discs by CM-H2DCFDA. ROS levels in the area posterior to the morphogenetic furrow in eye imaginal discs were higher in dUCH knockdown larvae (GMR > dUCH.IR) (b) than in control larvae (GMR > CS) (a). Eye imaginal discs of dUCH knockdown larvae treated with curcumin (GMR > dUCH.IR + curcumin) (c) showed decreased ROS levels in the area posterior to the morphogenetic furrow. White arrows indicate morphogenetic furrows, and scale bars indicate 100 μm. (d) Quantified data of the intensities of the region posterior to the morphogenetic furrow in eye imaginal discs shown in (a–c) (Tukey’s test; and ;; error bars represent the standard deviation of data). GMR > CS (GMR-GAL4/Y; +; +) and GMR > dUCH.IR (GMR-GAL4/Y; +; UAS-dUCH.IR/+).
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