Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 2

Research Article

Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown

Figure 2

Curcumin decreased ROS levels induced by the knockdown of dUCH in adult brains. Detection of ROS levels in adult brains by CM-H2DCFDA. ROS levels were higher in fly brains with the knockdown of dUCH (TH > dUCH.IR) (b) than in control fly brains (TH > CS) (a). ROS levels also decreased in adult fly brains with the knockdown of dUCH treated with curcumin (TH > dUCH.IR + curcumin) (c). The red dashed circles enclose the regions of interest, and scale bars indicate 100 μm. (d) Quantified data of the intensities of adult brains shown in (a–c) (one-way ANOVA; and ; ; error bars represent the standard deviation of data). TH > CS (w/Y; +; TH-GAL4/+) and TH > dUCH.IR (w/Y; +; TH-GAL4/UAS-dUCH.IR).

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