Curcumin Effectively Rescued Parkinson’s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown

Figure 7

Quantification of dopamine in adult fly brains. Curcumin did not affect dopamine levels in control fly brains (TH > CS and TH > CS + curcumin). The knockdown of dUCH in dopaminergic neurons resulted in lower dopamine levels in knockdown fly brains (TH > dUCH.IR) than in control fly brains (TH > CS). Curcumin reduced the negative impact of the dUCH knockdown on dopamine levels. Curcumin-treated knockdown flies (TH > dUCH.IR + curcumin) showed only slightly lower dopamine levels than those of control flies (TH > CS) (population size and biological replication ; error bars indicate the standard deviation of data). TH > CS (w/Y; +; TH-GAL4/+) and TH > dUCH.IR (w/Y; +; TH-GAL4/UAS-dUCH.IR).