Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats

Table 3

Effects of MeJA on antioxidant and inflammation parameters in the liver. C: controls treated with corn oil; C300: control treated with MeJA at the dose of 300 mg·kg⁻¹; A: arthritic rats treated with corn oil; A300: arthritic rats treated with MeJA at the dose of 300 mg·kg⁻¹; IBU: arthritic rats treated with ibuprofen at the dose of 30 mg·kg⁻¹, GSH: reduced glutathione; GSSG: oxidized glutathione; SOD: superoxide dismutase; MPO: myeloperoxidase.

Parameter	Groups
	C	C300	A	A300	IBU
GSH (nmol·mg^−1)	11.4 ± 0.6^a	12.0 ± 1.5^a	7.2 ± 0.3^b	12.3 ± 0.8^a	8.7 ± 0.7^b
GSSG (nmol·mg^−1)	1.5 ± 0.2^a	1.3 ± 0.1^a	1.7 ± 0.2^a	1.4 ± 0.3^a	1.6 ± 0.2^a
GSH + 2GSSG (nmol GSH units·mg^−1)	14.3 ± 0.8^a	14.6 ± 1.5^a	10.5 ± 0.3^b	14.1 ± 0.5^a	12.0 ± 0.4^a,b
GSH/GSSG ratio	8.7 ± 0.2^a	10.8 ± 1.2^a	4.8 ± 0.4^b	8.2 ± 1.1^a	6.5 ± 1.0^a,b
Catalase activity (mmol·min^−1·mg^−1)	1.1 ± 0.09^a	1.0 ± 0.02^a	0.2 ± 0.02^b	0.4 ± 0.04^c	0.3 ± 0.03^b
SOD activity (U·mg^−1)	1.9 ± 0.1^a	2.1 ± 0.2^a	1.7 ± 0.2^a	2.2 ± 0.2^a	2.4 ± 0.3^a
MPO activity (nmol·min^−1·mg^−1)	16.7 ± 0.1^a	16.0 ± 0.1^a	23.1 ± 0.8^b	16.9 ± 0.1^a	18.4 ± 1.6^a

The data are the error of the mean of 5 animals. Values with different superscript letters in the same line are different.