Propofol Protects Rat Cardiomyocytes from Anthracycline-Induced Apoptosis by Regulating MicroRNA-181a In Vitro and In Vivo

Figure 1

Antiproliferative effect ADM alone or combination treatment with propofol in cardiomyocytes. Morphological changes of H9c2 cells (a) and primary cardiomyocytes (b) in different treatment (control, prop 1 μg/ml, ADM 10 μM, and prop 1 μg/ml + ADM 10 μM) by microscope. Compared with the group treated with the combination of ADM with propofol, the antiproliferative effect of ADM alone on cardiomyocytes was significantly greater in H9c2 cells () (c) and primary cardiomyocytes () (d). The inhibition concentration of propofol in the combination treatment was maintained at 1 μg/ml, while the concentrations of ADM were 100 nM, 500 nM, 1 μM, and 10 μM. Each column or data point represents the mean ± S.D. (). The statistical analysis was performed with two-way ANOVA using Tukey’s test for pairwise comparisons. NS: not significant; compared with the ADM group.

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