Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway

Figure 5

Brusatol augmented the antitumour activity of gemcitabine in PANC-1 xenografts. (a) According to the above flow chart, the experimental design was utilized into in vivo studies. (b) Vernier calipers were used to measure tumour volume, and the following formula was used for calculation: , at the indicated time points. (c) The excised tumours from mice after the final treatment. (d) The tumour masses were weighed and compared. (e) The body weight was measured twice a week. (f) The body weight before sacrifice was compared. (g) The expression of Nrf2, NQO1, Ki-67, and active caspase-3 in xenograft tumour tissues was observed by immunohistochemical staining (magnification, 400x). compared with the control group. compared with the brusatol group and gemcitabine group.

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