Resveratrol Can Be Stable in a Medium Containing Fetal Bovine Serum with Pyruvate but Shortens the Lifespan of Human Fibroblastic Hs68 Cells

Table 4

Effect of FBS combined with pyruvate on Res degradation in MEM.

	Control	+FBS	+FBS; +Pyruvate	+Pyruvate
Day 0	100 ± 0.2	100 ± 2.0	100 ± 6.6	100 ± 2.2
Day 1	89.0 ± 1.9	94.5 ± 1.4	97.6 ± 0.3	78.3 ± 4.3
Day 7	69.0 ± 1.8	80.3 ± 2.7	97.5 ± 0.5	57.6 ± 1.4

Res at 200 μM was incubated for 0–7 days in minimum essential medium (MEM), which contained both or either 2.2 g/L sodium bicarbonate with 10% FBS (+FBS) and 1 mM pyruvate (+pyruvate) at 37°C in a CO₂ incubator supplied with 5% CO₂. The remaining Res levels (%) related to the peak area of Res on day 0 were determined by HPLC. Values (mean ± standard deviation; ) in the same column without a common letter are significantly different ().