The Effect of Chronic NO Synthase Inhibition on the Vasoactive and Structural Properties of Thoracic Aorta, NO Synthase Activity, and Oxidative Stress Biomarkers in Young SHR

Table 1

General cardiovascular parameters and biomarkers of oxidative stress in young SHR after chronic NO synthase inhibition.

		BW; (g)	HW; (mg)	HB; (mg/g)	KW; (mg)	KB; (mg/g)	ROM; (IU/l)	TTL; (μmol/l)	BAP; (meq/l)
SHR	8	248 ± 9.8	995.5 ± 42.3	4.0 ± 0.1	1829.7 ± 75.4	7.4 ± 0.1	297 ± 5	323 ± 15	2619 ± 37
SHR + L-NAME	7	180.4 ± 9.1	1026.3 ± 110.0	5.3 ± 0.1	1593.4 ± 99.7	8.8 ± 0.2	314 ± 27	278 ± 18	2708 ± 130

: number of rats; BW: body weight; HW: heart weight; HB: heart weight/body weight ratio; KW: kidney weight; KB: kidney weight/body weight ratio; ROM: reactive oxygen metabolites; TTL: total thiol levels; BAP: biological antioxidant potency. Values are the mean ± S.E.M. versus SHR.