The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model

Figure 3

Histological evaluation of renal tissue sections stained with H&E (original magnification, 400x). Sections from control (c) group (a), nanoliposomes (NL) group (b), lycopene (LYC) group (c), and encapsulated nanoliposomes (ENL) group (d) showing normal kidney morphology; (e) methotrexate (MTX) and (f) methotrexate-empty nanoliposomes (MTX-NL) groups with significant damage of renal cortex structures that include glomerular degeneration and interstitial inflammatory infiltration (marked with asterisk) with tubule cell vacuolation and apoptosis and with occasional tubule cast present (marked with arrow); (g) methotrexate-lycopene (MTX-LYC) group showing significantly milder kidney structure changes and (h) methotrexate-encapsulated nanoliposomes (MTX-ENL) group showing higher degree of recovery than those treated with free lycopene form.

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