The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model

Table 1

Stability of lycopene nanoliposomes in solutions with different pH values.

pH value	Samples	Residual rate (%) at different time points (minutes)
		0	20	40	60	120	180
6.4	Free lycopene	62.2 ± 0.6	42.4 ± 1.3	36.4 ± 1.8	33.9 ± 0.9	19.9 ± 1.1	9.0 ± 0.6
	Lycopene nanoliposomes	97.4 ± 0.3	88.4 ± 1.1	75.5 ± 0.3	75.0 ± 0.5	68.4 ± 1.4	58.2 ± 0.4
7.4	Free lycopene	75.15 ± 0.03	32.3 ± 0.6	22.8 ± 0.9	22.1 ± 1.6	16.1 ± 0. 8	4.2 ± 0.3
	Lycopene nanoliposomes	100 ± 0.0	74.2 ± 1.7	60.2 ± 1.9	59.6 ± 0.4	58.6 ± 0.9	53.9 ± 0.0
8	Free lycopene	66.4 ± 0.0	32.1 ± 1.6	25.1 ± 0.9	22.0 ± 0.6	9.5 ± 0.7	3.6 ± 0.3
	Lycopene nanoliposomes	100 ± 0.00	57.6 ± 0.1	53.8 ± 0.6	52.9 ± 0.1	45.5 ± 1.48	44.4 ± 0.2
9	Free lycopene	49.6 ± 0.141	10.4 ± 0.1	10.12 ± 0.2	6.5 ± 0.2	5.65 ± 0.2	4.1 ± 0.1
	Lycopene nanoliposomes	100 ± 0.00	94.9 ± 1.4	87.2 ± 1.1	62.1 ± 0.1	23.2 ± 1.5	20.9 ± 0.177

Data are presented as mean percentage values ± SD.