Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1/Hes1-Mediated Activation of Pten/Akt Signaling

<div>Effect of polydatin and DAPT on cardiac function in MI/R-injured diabetic rats. The diabetic animals received MI/R operation in the presence or absence of polydatin or DAPT treatment. The cardiac function was measured after 3 hours of reperfusion. (a) Chemical structure of polydatin (3,4<span class="nowrap"><svg height="11.4859pt" id="M28" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z" id="g50-31"></path></g></svg>,</span>5-trihydroxystilbene-3-<i>β</i>-D-glucoside, C<sub>20</sub>H<sub>22</sub>O<sub>8</sub>). (b) Bar diagram showing left ventricular systolic pressure. (c) and (d) Bar diagram showing first derivative of left ventricular pressure (+dP/dt<sub>max</sub> and −dP/dt<sub>max</sub>). The results are expressed as the mean ± SEM. <svg height="8.55521pt" id="M29" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 27.8368 8.55521" width="27.8368pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z" id="g113-111"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" id="g117-34"></path></g><g transform="matrix(.013,0,0,-0.013,21.421,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 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66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path></g></svg> versus the MI/R + V group, and <svg height="11.8082pt" id="M32" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.1712 52.3159 11.8082" width="52.3159pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M554 -9C527 -24 450 -47 393 -47C190 -47 121 88 121 219C121 405 248 538 435 538C571 538 672 461 672 324C672 188 591 120 529 119C504 118 499 130 509 181C524 263 542 344 558 409C546 409 536 411 521 414C509 417 485 422 471 422C409 421 354 390 309 348C250 292 227 214 227 159C227 100 252 74 276 74C323 74 416 153 448 201L450 200L440 146C431 103 432 74 486 74C622 74 725 187 725 323C725 460 623 581 440 581C246 581 54 444 53 208C53 4 199 -96 359 -96C429 -96 496 -82 566 -42L554 -9ZM430 378C449 378 471 373 484 366C478 338 469 292 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MI/R, myocardial ischemia-reperfusion; V, vehicle; LVSP, left ventricular systolic pressure.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1/Hes1-Mediated Activation of Pten/Akt Signaling 