Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 2

Research Article

Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1/Hes1-Mediated Activation of Pten/Akt Signaling

Figure 2

Effect of polydatin and DAPT on cardiac function in MI/R-injured diabetic rats. The diabetic animals received MI/R operation in the presence or absence of polydatin or DAPT treatment. The cardiac function was measured after 3 hours of reperfusion. (a) Chemical structure of polydatin (3,4,5-trihydroxystilbene-3-β-D-glucoside, C20H22O8). (b) Bar diagram showing left ventricular systolic pressure. (c) and (d) Bar diagram showing first derivative of left ventricular pressure (+dP/dtmax and −dP/dtmax). The results are expressed as the mean ± SEM. animals per group. versus the sham group, versus the MI/R + V group, and versus the MI/R + PD group. MI/R, myocardial ischemia-reperfusion; V, vehicle; LVSP, left ventricular systolic pressure.

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