Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1/Hes1-Mediated Activation of Pten/Akt Signaling
Effect of polydatin and DAPT on myocardial nitrative stress in MI/R-injured diabetic rats. The diabetic animals received MI/R operation in the presence or absence of polydatin or DAPT treatment. The measurement was performed after 3 hours of reperfusion. (a) Bar diagram showing iNOS expression. Top images: representative blots. (b) Bar diagram showing eNOS phosphorylation level. Top images: representative blots. (c) Bar diagram showing NO metabolites level. (d) Representative myocardial immunohistochemistry images of nitrotyrosine (×200, bar = 200 μm). (e) Bar diagram showing nitrotyrosine intensity. (f) Bar diagram showing myocardial nitrotyrosine content. The results are expressed as the mean ± SEM. samples per group. / versus the sham group, / versus the MI/R + V group, and / versus the MI/R + PD group. MI/R, myocardial ischemia-reperfusion; V, vehicle; PD, polydatin.
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