Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers
NADPH oxidase inhibitors are neuroprotective against Aβ oligomers. (a) Neurons were treated with Αβ (5 μM) for 60 min, and ROS generation was monitored with CM-H2DCFDA (30 μM). Apocynin (5 nM), DPI (0.5 μM), and EUK-134 (100 nM) reduced Αβ-induced ROS generation in neurons. (b) The toxicity of Aβ oligomers (5 μM) in cultured cortical neurons as measured 24 h later with the LDH viability assay is prevented by the coapplication of Aβ oligomers with NOX inhibitor DPI. Data represent of the CM-H2DCFDA/calcein and LDH signals in cultures, expressed as a percentage of control untreated levels (100%). compared with untreated cells; , compared with Aβ-treated cells.
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