Research Article

[Retracted] The Protective Role of Brain CYP2J in Parkinson’s Disease Models

Figure 1

The TLR4-MyD88 signaling pathway was involved in the inhibition of CYP2J2 levels by LPS treatment in U251 cells. Compared with the control, LPS treatment decreased CYP2J and CREB mRNA levels in cells (a). The LPS-induced inhibition of CYP2J2 and CREB mRNA levels was abolished by CLI-095 and attenuated by ST 2825. Moreover, CLI-095 and ST 2825 attenuated the LPS-induced decrease in p-CREB protein levels in cells (b). ChIP data shows that the LPS-induced decrease of p-CREB protein binding to the CYP2J2 promoter by LPS was attenuated by CLI-095 and ST 2825 (c). Data were analyzed by one-way ANOVA. The data are ; , , , and compared with respective controls.