Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 2

Review Article

SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1α

Figure 2

Illustration of adopted and simplified mPTP complex [53]. Increased mitochondrial oxidative stress primes CypD to bind with ANT (thiol oxidation-dependent), and VDAC-ANT complex causes mPTP opening. Increased activities of Sirt3 inhibit CypD-ANT bond and subsequently suppress mPTP opening. For detailed mPTP complex structure please refer to Rizwan, M. et al. [53]

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