Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest-Old Population

Figure 2

Major enriched networks of common genes and the top ranked pathway suggesting key contributors to longevity in aspect of DNA repair. (a) Pathways and ontologies enriched in these genes shown in a bar graph. x-axis indicates the number of overlapped genes with elements of each pathway/ontology while y-axis shows the name of statistically meaningful pathways/ontologies ( value < 0.05). (b) The most enriched pathway, “persisted DNA repair triggers genomic instability,” and direct pathway analyzed previously were combined using Pathway Studio Web (version 11.4.0.8) to explore major genes including candidate longevity-associated loci in DNA repair to provide better visualization. Green highlighted entities indicate common genes collected by gene set comparison.

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